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Publications
Siggs OM, Miosge LA, Yates AL, Kucharska EM, Sheahan D, Brdicka T, Weiss A, Liston A, Goodnow CC. (2007)
Opposing Functions of the T cell Receptor Kinase ZAP-70 in Immunity and Tolerance Differentially Titrate in Response to Nucleotide Substitutions.
Immunity 27(6):912-26
Yu D, Tan AH, Hu X, Athanasopoulos V, Simpson N, Silva DG, Hutloff A, Giles KM, Leedman PJ, Lam KP, Goodnow CC, Vinuesa CG. (2007)
Roquin Represses Autoimmunity by Limiting inducible T-cell co-stimulator messenger RNA.
Nature 450(7167):299-303
Nijnik A, Woodbine L, Marchetti C, Dawson S, Lambe T, Liu C, Rodrigues NP, Crockford TL, Cabuy E, Vindigni A, Enver T, Bell JI, Slijepcevic P, Goodnow CC, Jeggo PA, Cornall RJ. (2007)
DNA repair is limiting for haematopoietic stem cells during ageing.
Nature. 447(7145):686-90
Gosling KM, Makaroff LE, Theodoratos A, Kim YH, Whittle B, Rui L, Wu H, Hong NA, Kennedy GC, Fritz JA, Yates AL, Goodnow CC, Fahrer AM. (2007)
A mutation in a chromosome condensing condensin II subunit, kleisin beta, specifically disrupts T cell development.
Proc Natl Acad Sci USA. 104(30):12445-50
Kennedy CL, O'Bryan MK. (2006)
N-ethyl-N-nitrosourea (ENU) mutagenesis and male fertility research.
Hum Reprod Update. 12(3): 293-301
O'Bryan MK, Kretzer D. (2006)
Mouse models of genes involved in impaired spermatogenesis.
Int J of Andrology 29:76-89
Miosge LA, Goodnow CC. (2005)
Genes, pathways and checkpoints in lymphocyte development and homeostasis.
Immunology and Cell Biology 83: 318-335
Kennedy, CL, O.Connor, AE, Sanchez-Partida, LG, Holland, MK, Goodnow, CC, de Kretser, DM, O.Bryan MK. (2005)
A repository of ENU mutant mouse lines and their potential for male fertility research.
Mol Hum Reprod 11:871-880
Papathanasiou P, Goodnow CC. (2005)
Connecting mammalian genome with phenome by ENU mutagenesis: gene combinations specifying the immune system.
Annual Review in Genetics 39:241-62
Vinuesa C, Tangye S, Moser B and Mackay C. (2005)
T follicular helper cells and antibody responses.
Nature Rev Immunol. 5, 853-865
Goodnow C, Sprent J, Fazekas de St Groth B and Vinuesa C. (2005)
Cellular and genetic mechanisms of self-tolerance and autoimmunity.
Nature, 435, 7042.
Vinuesa, C.G., Cook, M.C., Angelucci, C., Athanasopoulos, V., Rui, L., Hill, K.M., Y, Yu, D., Domaschenz, H., Whittle, B., Lambe, T., Roberts, I.S., Copley, I.R., Bell, J.I., Cornall, R.J., and Goodnow, C.C. (2005)
A novel RING-type ubiquitin ligase family member essential to repress follicular helper T cells and autoimmunity.
Nature 435: 452-458
Vinuesa C and Goodnow C. (2004)
Illuminating autoimmune regulators through controlled variation of the mouse genome sequence.
Immunity, 20:669-79
Papathanasiou P, Perkins AC, Cobb BS, Ferrini R, Sridharan R, Hoyne GF, Nelms KA, Smale ST and Goodnow CC. (2003)
Widespread failure of hematolymphoid differentiation caused by a recessive niche-filling allele of the Ikaros transcription factor.
Immunity 19; 131-144.
Jun, J.E. Wilson, L.E. Vinuesa, C.G. Lesage, S. Bléry, M, Miosge, L.A. Cook, M.C. Kucharska, E.M. Dolmashenz, H, Hong, N.A. Glynne, R.J. Hara, H. Penninger, J.M. Nelms, K.A. Goodnow, C.C. (2003)
Identifying the MAGUK-protein Carma-1 as a central regulator of humoral immune responses and atopy by genome wide mouse mutagenesis.
Immunity 18| : 751-762
Loy, A., Goodnow, C. (2002)
Novel approaches for identifying genes regulating lymphocyte development and function.
Current Opinion in Immunology, 14:260-5.
Miosge, L.M. Blasioli, J. Bléry, M. Goodnow, C.C. (2002)
Analysis of an ENU-generated mouse mutation defines a cell intrinsic role of NFkB2 in regulating circulating B cell numbers.
J. Exp. Med 196:| 1113-1119.
Nelms, K. & Goodnow, C.C. (2001)
Genome-wide mutagenesis with ENU to discover immune regulators.
Immunity 15, 409-418
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